| Home | Score | Away | League | Time (CST) |
|---|---|---|---|---|
| AC Boise | 1:1 | One Knoxville | American USL League One | 09:30 |
| Birmingham Legion | 1:2 | Detroit City FC | American USL Championship | 08:00 |
| Peoria City | 1:4 | St. Louis Ambush | USL League Two | 08:30 |
| Fortaleza | 2:0 | Ponte Preta | Brazilian Serie B | 08:00 |
| O'Higgins | 4:1 | Colo-Colo | Copa Chile | 08:30 |
| Deportivo Santo Domingo | 1:0 | Independiente Juniors | Ecuadorian Serie B | 08:00 |